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KMID : 0438420090160020065
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Korean Journal of Bone Metabolism
2009 Volume.16 No. 2 p.65 ~ p.69
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RANK Signaling-based New Drug Targets for Osteoporosis
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Choi Han-Kyoung
Kim Kyung-Hee
Shin Ji-Hye
Jang Hyun-Duk
Lee Soo-Young
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Abstract
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Increased osteoclastic bone resorption causes the loss in bone density observed in human diseases such as osteoporosis and arthritis. The discovery of the RANKL/RANK axis as the final effector of bone destruction has generated great expectations regarding the potential of some antagonists for the treatment of patients with various metabolic and inflammatory bone disorders. The signaling cascades initiated by RANKL uncover several new classes of antiresorptive therapeutic targets. Unraveling the entire RANK signaling networks will be beneficial for the development of new generations of therapeutics with higher efficacy and fewer side effects.
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KEYWORD
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RANKL, RANK, Osteoclast, Bone resorption, Osteoporosis
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